MovDisordV3, Main, Exploration, bibRecord, 001046

Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?

Identifieur interne : 001046 ( Main/Exploration ); précédent : 001045; suivant : 001047

Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?

Auteurs : Claire Hinnell [Royaume-Uni] ; Catherine S. Hurt [Royaume-Uni] ; Sabine Landau [Royaume-Uni] ; Richard G. Brown [Royaume-Uni] ; Michael Samuel [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0113830

Descripteurs français

Pascal (Inist)
- Trouble moteur, Maladie de Parkinson, Etat dépressif, Pathologie du système nerveux, Etude comparative, Etat sanitaire.

English descriptors

KwdEn :
- Comparative study, Depression, Health status, Motor system disorder, Nervous system diseases, Parkinson disease.

Abstract

Evidence suggests that both motor and nonmotor symptoms contribute to health status in Parkinson's disease. Less clear is how much change in health status can be expected if these clinical variables change. In addition, anxiety, separate from depression, has rarely been examined as a predictor of health status. We used hierarchical multiple regression analysis and standardized beta coefficients in a prevalent cohort of 462 patients with Parkinson's disease to explore the relative impact on health status (measured using the Parkinson's Disease Questionnaire) of 5 well-recognized symptom domains in Parkinson's disease: motor signs, depression, anxiety, cognition, and other nonmotor symptoms. In the health status scores, 19.6% of variance was explained by age, number of comorbidities, disease duration, and levodopa equivalent dose. Younger age predicted worse health status. A full regression model containing baseline variables and all 5 symptom domains explained 56% of the variance in health status. The standardized beta coefficient for depression was 2.1, 1.6, and 1.3 times that of motor signs, anxiety, and other nonmotor symptoms, respectively. Our findings provide a ranking order of clinical variables for their relative impact on health status in Parkinson's disease and show that depression has more than twice the impact of motor signs on health status. Anxiety and other nonmotor symptoms are also important separate determinants of poor health status in Parkinson's disease. Our results will help to guide the development of individual care and service planning for patients with Parkinson's disease.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000260
to stream PascalFrancis, to step Curation: 002A54
to stream PascalFrancis, to step Checkpoint: 000119
to stream Main, to step Merge: 001098
to stream Main, to step Curation: 001046

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?</title>
<author><name sortKey="Hinnell, Claire" sort="Hinnell, Claire" uniqKey="Hinnell C" first="Claire" last="Hinnell">Claire Hinnell</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, King's College Hospital, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S." last="Hurt">Catherine S. Hurt</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Psychology, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Biostatistics, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Psychology, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, MRC Centre for Neurodegeneration Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, King's College Hospital, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>East Kent Hospitals University NHS Foundation Trust, William Harvey Hospital</s1>
<s2>Ashford</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Ashford</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0113830</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0113830 INIST</idno>
<idno type="RBID">Pascal:12-0113830</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000260</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002A54</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000119</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Hinnell C:nonmotor:versus:motor</idno>
<idno type="wicri:Area/Main/Merge">001098</idno>
<idno type="wicri:Area/Main/Curation">001046</idno>
<idno type="wicri:Area/Main/Exploration">001046</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?</title>
<author><name sortKey="Hinnell, Claire" sort="Hinnell, Claire" uniqKey="Hinnell C" first="Claire" last="Hinnell">Claire Hinnell</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, King's College Hospital, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S." last="Hurt">Catherine S. Hurt</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Psychology, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Biostatistics, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Psychology, King's College London, Institute of Psychiatry, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, MRC Centre for Neurodegeneration Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, King's College Hospital, King's Health Partners</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>East Kent Hospitals University NHS Foundation Trust, William Harvey Hospital</s1>
<s2>Ashford</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Ashford</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term>
<term>Depression</term>
<term>Health status</term>
<term>Motor system disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term>
<term>Maladie de Parkinson</term>
<term>Etat dépressif</term>
<term>Pathologie du   système nerveux</term>
<term>Etude comparative</term>
<term>Etat sanitaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence suggests that both motor and nonmotor symptoms contribute to health status in Parkinson's disease. Less clear is how much change in health status can be expected if these clinical variables change. In addition, anxiety, separate from depression, has rarely been examined as a predictor of health status. We used hierarchical multiple regression analysis and standardized beta coefficients in a prevalent cohort of 462 patients with Parkinson's disease to explore the relative impact on health status (measured using the Parkinson's Disease Questionnaire) of 5 well-recognized symptom domains in Parkinson's disease: motor signs, depression, anxiety, cognition, and other nonmotor symptoms. In the health status scores, 19.6% of variance was explained by age, number of comorbidities, disease duration, and levodopa equivalent dose. Younger age predicted worse health status. A full regression model containing baseline variables and all 5 symptom domains explained 56% of the variance in health status. The standardized beta coefficient for depression was 2.1, 1.6, and 1.3 times that of motor signs, anxiety, and other nonmotor symptoms, respectively. Our findings provide a ranking order of clinical variables for their relative impact on health status in Parkinson's disease and show that depression has more than twice the impact of motor signs on health status. Anxiety and other nonmotor symptoms are also important separate determinants of poor health status in Parkinson's disease. Our results will help to guide the development of individual care and service planning for patients with Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hinnell, Claire" sort="Hinnell, Claire" uniqKey="Hinnell C" first="Claire" last="Hinnell">Claire Hinnell</name>
</region>
<name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name>
<name sortKey="Brown, Richard G" sort="Brown, Richard G" uniqKey="Brown R" first="Richard G." last="Brown">Richard G. Brown</name>
<name sortKey="Hurt, Catherine S" sort="Hurt, Catherine S" uniqKey="Hurt C" first="Catherine S." last="Hurt">Catherine S. Hurt</name>
<name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name>
<name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name>
<name sortKey="Samuel, Michael" sort="Samuel, Michael" uniqKey="Samuel M" first="Michael" last="Samuel">Michael Samuel</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001046 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001046 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:12-0113830
   |texte=   Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?

Nonmotor Versus Motor Symptoms: How Much Do They Matter to Health Status in Parkinson's Disease?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri